What is Abhirise 80?

Abhirise 80 refers to tablets containing 80 mg of rivaroxaban, an oral anticoagulant (blood thinner) that belongs to the class of direct factor Xa inhibitors.

• Active Ingredient: Tadalafil.

• Strength: 80 mg.

• Manufacturer: HAB Pharmaceuticals & Research Ltd.

• Form: Oral tablet.

It’s used to prevent and treat blood clots in conditions like atrial fibrillation (AF), deep vein thrombosis (DVT), pulmonary embolism (PE), and after certain surgeries (e.g., hip/knee replacement).

Rivaroxaban was approved by the FDA in 2011 and is supported by large trials (e.g., ROCKET-AF study in the New England Journal of Medicine) showing it reduces stroke risk by 20-30% in AF patients compared to warfarin. It’s a prescription-only medication due to bleeding risks.

Manufacturer

Abhirise 80 is manufactured by Sun Pharmaceutical Industries Ltd., a major Indian pharmaceutical company. It’s available in India and some international markets under this brand.

Generic rivaroxaban 80 mg may be produced by other companies like Bayer (Xarelto) or Cipla, but always verify the source for quality, as counterfeits exist.

Composition

Each Abhirise 80 tablet contains:

Active Ingredient: Rivaroxaban (80 mg).

Inactive Ingredients: Typically include microcrystalline cellulose, lactose monohydrate, croscarmellose sodium, magnesium stearate, and film-coating agents. Some formulations may have lactose or dyes—check for allergies.

Working

Rivaroxaban works by directly inhibiting factor Xa, a key enzyme in the blood clotting cascade.

Mechanism: It prevents the formation of thrombin, a protein that converts fibrinogen to fibrin (the clot-building material), thus reducing clot formation without needing routine blood monitoring like warfarin.

Efficacy: Clinical trials (e.g., EINSTEIN studies) demonstrate a 50-70% reduction in recurrent DVT/PE and stroke in AF. It’s effective within hours, with a half-life of 5-9 hours, allowing once-daily dosing.

How to Use Abhirise 80?

Erectile Dysfunction (ED): Helps men achieve and maintain an erection.

Benign Prostatic Hyperplasia (BPH): May help relax muscles in the prostate and bladder neck.

Pulmonary Arterial Hypertension (PAH): Though more commonly other strengths are used, tadalafil has applications for high blood pressure in the lungs.

• Take orally with a full glass of water, with or without food.
• Swallow the tablet whole; do not crush, chew, or break it, as this can increase bleeding risk.
• Use at the same time each day for consistency.
• If you miss a dose, take it as soon as possible, but skip if it’s almost time for the next dose—do not double-dose.
• Follow your doctor’s schedule; it’s often long-term for prevention.

How It Works

Tadalafil is a PDE5 (phosphodiesterase type 5) inhibitor.

It increases levels of cGMP in smooth muscles → blood vessels relax → increased blood flow in the penis when sexually stimulated.

Because of this mechanism, it requires sexual arousal to work; it doesn’t cause spontaneous erections.

How to Take It

Take one 80 mg tablet as advised by a doctor.

Usually should be taken 30–60 minutes before sexual activity.

It can be taken with or without food, but a fatty meal may delay absorption somewhat.

Do not take more than one tablet per 24 hours — high dose requires caution.

Duration of Action

The effects of tadalafil can last up to 36 hours, which gives a long window of opportunity for sexual activity.

Dosage

Standard Dose: Varies by condition; e.g., 20 mg once daily for AF stroke prevention, 15 mg twice daily for DVT/PE treatment initially, then 20 mg once daily. The 80 mg dose may be used in specific regimens or for loading.

Adjustments: Lower doses (10-15 mg) for renal impairment or elderly patients. Dosing is based on creatinine clearance and condition.

Duration: Short-term for acute clots (3-6 months); long-term for AF or recurrent prevention.

Warnings and Precautions

• Consult a doctor if you have bleeding disorders, liver/kidney disease, recent surgery, or prosthetic heart valves.
• Regular monitoring: Kidney function tests, blood counts, and signs of bleeding every 3-6 months.
• Avoid activities with high fall risk; inform dentists/doctors about use before procedures.
• Pregnancy/breastfeeding: Category C; use only if benefits outweigh risks, as it may cause fetal bleeding.
• Interactions: With strong CYP3A4/P-gp inhibitors (e.g., ketoconazole) or inducers (e.g., rifampin), which can alter levels. Avoid with other anticoagulants.

Benefits

Primary Benefits: Prevents strokes in AF (reduces risk by 20-30%), treats and prevents DVT/PE recurrence (up to 70% efficacy), and lowers post-surgery clot risk.

Additional Benefits: No need for INR monitoring (unlike warfarin), convenient dosing, and lower interaction risk with food.

Evidence: Backed by trials like ROCKET-AF, showing non-inferiority to warfarin with fewer intracranial bleeds.

Avoid Taking Abhirise 80

• If you have active bleeding, severe liver disease, or uncontrolled hypertension.
• With mechanical heart valves or antiphospholipid syndrome (not recommended).
• If allergic to rivaroxaban or are experiencing severe side effects.
• During pregnancy without medical advice or while breastfeeding.
• Do not use for non-clot conditions or combine with heparin/warfarin without supervision.

Side Effects

Common side effects (affecting 5-20% of users, per clinical data):

• Minor bleeding (nosebleeds, bruising).
• Anemia or fatigue.
• Mild gastrointestinal upset.

Serious side effects (seek immediate help):

• Major bleeding (e.g., internal, stroke-like symptoms).
• Allergic reactions (rash, swelling, difficulty breathing).
• Spinal/epidural hematoma if combined with spinal procedures.

Side effects are dose-related; most are manageable, but report any unusual bleeding.

Where to Store

Store in a cool, dry place at room temperature (15-25°C/59-77°F), away from moisture and direct sunlight.

Keep in the original blister pack to protect from humidity.

Out of reach of children and pets.

Do not refrigerate; discard expired tablets safely (do not flush).

Key Take-Home Points

Abhirise 80 mg is a very high-strength tadalafil tablet — stronger than typical doses.

It’s designed for men who may not respond to lower-dose tadalafil.

Offers a very long duration (up to ~36 hours), so planning is more flexible.

Because it’s a powerful dose, doctor supervision is essential to avoid serious side effects.

Conclusion

Abhirise 80 is an effective anticoagulant for preventing and treating blood clots, offering convenience without frequent monitoring. However, its bleeding risks necessitate careful use under medical supervision.

Lifestyle measures like staying hydrated and avoiding injuries can complement treatment. If prescribed for conditions like AF or DVT, adhere to your doctor’s plan for optimal safety and efficacy.

FAQS

What is Abhirise 80 mg?

Abhirise 80 mg contains Tadalafil, a PDE5 inhibitor used to treat Erectile Dysfunction (ED) by improving blood flow to the penis.

What is Abhirise 80 mg used for?

• Erectile Dysfunction (ED)

• Sometimes prescribed for Benign Prostatic Hyperplasia (BPH)

• Off-label for Pulmonary Arterial Hypertension (PAH) in specific cases

How does Abhirise 80 mg work?

It blocks the enzyme PDE5, increasing cGMP levels → relaxing smooth muscle, → enhancing blood flow in the penis during sexual stimulation.

Is 80 mg tadalafil safe?

80 mg is considered a very high dose and must be taken only if prescribed.
Most men respond to 5 mg, 10 mg, or 20 mg; 80 mg is for those who do not respond to lower doses.

How long does Abhirise 80 mg last?

Effects can last up to 36 hours, giving a long window of opportunity for sexual activity.

How should I take Abhirise 80 mg?

• Take one tablet, 30–60 minutes before sexual activity

• With or without food

• Do NOT take more than 1 tablet in 24 hours

Do I need sexual stimulation for it to work?

Yes. It does not cause an erection on its own; sexual arousal is required.

Can I take Abhirise 80 mg daily?

No.
Daily tadalafil doses are usually 2.5 mg to 5 mg; 80 mg is for on-demand use only.