Imiquimod Cream 5% w/w (Imiquad Cream) 12.5

Imiquimod Cream 5% w/w, branded as Imiquad Cream, is a topical immunomodulator used to treat certain skin conditions. The “12.5” likely refers to the pack size (e.g., 12.5 grams or a specific quantity like 12.5 mg per application, but typically it’s a 12.5g tube).

Imiquimod Cream 5% w/w is prescription-only and should be used under medical supervision.

Note: This is general information, not medical advice—consult a dermatologist for diagnosis and treatment, as misuse can cause irritation or ineffective results.

Key Facts and Mechanism

Active Ingredient: Imiquimod 5% w/w (weight by weight), a synthetic compound that stimulates the immune system.

How It Works: Activates toll-like receptors on skin cells, triggering an immune response that fights abnormal cells (e.g., viral or precancerous). It induces cytokines like interferon-alpha, leading to local inflammation and clearance of lesions.

Form: White cream for topical application; typically applied 3-5 times weekly at night and washed off after 6-10 hours.

Indications and Efficacy

Primary Uses:

Genital warts (condyloma acuminata) are caused by HPV.

Actinic keratosis (precancerous skin lesions from sun damage).

Superficial basal cell carcinoma (a type of skin cancer).

Efficacy Evidence: Clinical trials (e.g., in JAMA Dermatology) show clearance rates of 50-80% for genital warts after 12-16 weeks, and 70-90% for actinic keratosis. For basal cell carcinoma, it achieves histological clearance in 80-90% of cases (per FDA data). Success depends on adherence and lesion type.

Duration: Treatment courses last 4-16 weeks, with follow-up to monitor recurrence.

Unique Aspects: Non-invasive alternative to surgery; works by boosting local immunity rather than directly killing pathogens.

Safety and Side Effects

Common Side Effects: Local reactions like redness, itching, burning, or flaking (occur in 70-90% of users, per package insert). These are usually mild and resolve post-treatment.

Serious Risks: Severe irritation, ulceration, or infection; rare systemic effects like flu-like symptoms. Avoid in immunocompromised patients or those with autoimmune diseases.

Precautions: Not for use on mucous membranes (e.g., inside vagina/anus) without guidance; avoid sun exposure during treatment. Pregnancy category C—use only if benefits outweigh risks.

Interactions: May enhance effects of other topical agents; no major systemic drug interactions reported.

Availability and Purchasing

Where to Buy: Available at licensed pharmacies with a prescription. Branded as Imiquad by Glenmark or generics from other manufacturers.

Online Options: Sites like Genericmedsstore may offer it, with prices around $10-20 per 12.5g tube (depending on region and bulk). Shipping is often international; confirm authenticity to avoid counterfeits.

Legal Notes: Prescription required; importing may face customs restrictions. In the US, check FDA-approved versions; internationally, verify with local health authorities.

Alternatives and Tips

Other Options: Cryotherapy, laser, or other creams like fluorouracil for similar conditions. For warts, podofilox or surgical removal.

Application Tips: Apply thinly to clean, dry skin; use gloves to avoid transfer. Monitor for adverse reactions and report to a doctor.

Resources: Refer to FDA labeling or DermNet NZ for details; seek professional application guidance.