Isentress 400 mg — Overview
Isentress 400 refers to raltegravir 400 mg tablets, an antiretroviral medication used in combination therapy for HIV-1 infection.
It’s an integrase strand transfer inhibitor (INSTI) that prevents HIV from integrating into host DNA.
Note: This is not medical advice—HIV treatment requires prescription and monitoring by an infectious disease specialist. Raltegravir is part of highly active antiretroviral therapy (HAART) regimens.
Isentress 400 mg is an antiretroviral medication used in the treatment of HIV-1 infection (Human Immunodeficiency Virus).
It contains Raltegravir as the active ingredient and is prescribed as part of combination antiretroviral therapy (ART) to control HIV infection.
Manufacturer
MSD Pharmaceuticals Pvt. Ltd. (Merck Sharp & Dohme)
Drug Class
Integrase Strand Transfer Inhibitor (INSTI) — a class of HIV drugs that block the viral enzyme integrase, preventing the virus from integrating its DNA into human cells.
How Isentress 400 mg Works
HIV replicates by inserting its genetic material into human DNA using the integrase enzyme.
Raltegravir — the active ingredient — blocks this enzyme, stopping the virus from multiplying and lowering the amount of HIV in the blood (viral load).
🧠 This helps improve immune system function and reduces the risk of HIV-related complications.
Dosage & Administration
| Group | Typical Dose | Frequency |
|---|---|---|
| Adults | 400 mg tablet | Twice daily |
| Alternative dose (Isentress HD) | 1200 mg tablet | Once daily (as prescribed) |
Can be taken with or without food
Swallow whole with water
Take the medicine at the same time every day
⚠️ Do not stop taking Isentress without consulting your doctor — doing so may cause drug resistance.
Uses
Treatment of HIV-1 infection in adults and children (weighing ≥ 25 kg)
Used in combination with other antiretroviral drugs
Helps reduce viral load and increase CD4 cell count
Possible Side Effects
Common:
Serious (rare, seek medical attention):
-
Severe skin rash or allergic reactions
-
Muscle pain or weakness (may indicate rhabdomyolysis)
-
Depression or mood changes
-
Liver problems (yellowing of eyes/skin)
Precautions & Warnings
| Condition | Advice |
|---|---|
| Pregnancy/Breastfeeding | Consult doctor — limited data |
| Liver/Kidney disease | Use cautiously |
| History of muscle disorders | Inform doctor |
| Allergic to Raltegravir | Avoid use |
Avoid taking antacids containing aluminum or magnesium within 2 hours of Isentress — they reduce its absorption.
Drug Interactions
Isentress may interact with:
-
Rifampin (reduces Isentress levels)
-
Antacids with aluminum or magnesium
-
Other antiretroviral drugs — dose adjustment may be required
Always inform your doctor about all medicines or supplements you use.
Storage
Store below 30°C (86°F)
Keep in original packaging
Protect from moisture and light
Keep away from children
Key Takeaway
Isentress 400 mg (Raltegravir) is a safe and effective antiretroviral drug used in HIV management.
It helps suppress the virus, boosts immune strength, and prevents disease progression — but must always be taken exactly as prescribed.
Conclusion
Isentress 400 (raltegravir 400 mg) is a cornerstone antiretroviral for HIV-1 management, offering effective viral suppression with a favorable safety profile. Below is a summary of key takeaways, emphasizing its role in treatment regimens.
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