Xeloda (Capecitabine)

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Description

Xeloda Overview

Xeloda is a brand name for capecitabine, a prescription chemotherapy medication used to treat certain types of cancer. It belongs to a class of drugs called antimetabolites, which interfere with cancer cell growth.

Xeloda is an oral chemotherapy drug used to treat several types of cancer. It belongs to a class of drugs called antimetabolites, which stop cancer cell growth.

Uses

Xeloda is commonly prescribed for:

✔️ Breast cancer

— Especially metastatic or after other treatments fail.

✔️ Colorectal cancer

— Stage III as part of adjuvant therapy
— Metastatic colorectal cancer

✔️ Gastric (stomach) cancer

— Often in combination with other chemo drugs

How It Works

Capecitabine is a prodrug that converts to 5-fluorouracil (5-FU) in the body, inhibiting DNA synthesis in cancer cells and stopping their division. It’s designed for oral use, mimicking intravenous 5-FU. Clinical trials (e.g., in The Lancet Oncology) show it improves survival in 20-40% of patients with metastatic colorectal or breast cancer.

Xeloda is converted in the body to 5-fluorouracil (5-FU), which interferes with DNA synthesis in rapidly dividing cells (like cancer cells), leading to cell death.

Common Uses

Breast Cancer: For metastatic or adjuvant treatment after surgery.

Colorectal Cancer: For metastatic disease or as adjuvant therapy.

Other Cancers: Off-label for gastric or pancreatic cancer. It’s not for early-stage cancers without metastasis.

Dosage

The dose varies based on:

  • Cancer type

  • Body surface area (height + weight)

  • Other chemotherapy is being used

Typical schedule:

  • Taken twice daily for 14 days

  • Followed by 7 days off
    (One cycle = 21 days)

👉 Never adjust your dose without your oncologist’s advice.

Common Side Effects

  • Diarrhea

  • Hand-foot syndrome (redness, pain, peeling)

  • Nausea, vomiting

  • Loss of appetite

  • Fatigue

  • Mouth sores

  • Low blood counts (anemia, neutropenia)

When to Contact Your Doctor Immediately

  • Severe diarrhea (4+ times/day)

  • Painful hand-foot syndrome

  • Persistent vomiting

  • Fever or infection signs

  • Chest pain

  • Severe fatigue or dehydration

Drug Interactions

Tell your doctor if you take:

  • Blood thinners (especially warfarin)

  • Phenytoin

  • Allopurinol

  • Antacids

If you want, I can help you with:

  • Does the detail match your prescription

  • How to manage side effects

  • How it compares to other chemo options

  • Whether it’s safe with your other medicines

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