Glycomet-GP 3 (Metformin/Glimepiride)

What is Glycomet-GP 3?

Glycomet-GP 3 is an anti-diabetic medication used for treating Type 2 Diabetes Mellitus.
It is a combination medicine containing:

• Glimepiride 3 mg

• Metformin (SR/ER) 500 mg or 850 mg (varies by brand)

Glycomet-GP 3 helps control high blood sugar when diet, exercise, and single-drug therapy are not enough.

Manufacturer

The most common manufacturer is:

• USV Pvt. Ltd. (India)

However, other pharmaceutical companies may also produce the same combination.

Composition

Each tablet contains:

• Glimepiride – 3 mg (a sulfonylurea)

• Metformin Hydrochloride – 500 mg or 850 mg (typically sustained-release)

Inactive ingredients vary based on brand (binders, coating agents, etc.).

Working (Mechanism of Action)

1. Glimepiride

• Stimulates the pancreas to release more insulin.

• Helps lower blood sugar after meals.

2. Metformin

• Reduces glucose production in the liver.

• Improves insulin sensitivity.

• Reduces sugar absorption in the intestines.

Combined effect:
Better blood sugar control throughout the day and after meals.

How to Use Glycomet-GP 3

• Take the tablet with food, ideally with breakfast or your largest meal.

• Swallow whole with water—do not crush or chew SR/ER tablets.

• Take it at the same time daily.

Your doctor will adjust the dose based on blood sugar levels.

Dosage

Typical dose:

• One tablet once daily
  OR

• One tablet twice daily (depending on severity and doctor’s advice)

Dosage depends on:

• HbA1c level

• Fasting/PP blood sugar

• Previous medication use

• Weight

• Kidney/liver function

Never self-adjust the dose; changes must be supervised.

Warnings and Precautions

Do NOT take if:

• You have Type 1 Diabetes

• You have severe kidney or liver problems

• You are prone to lactic acidosis

• You have severe dehydration or infections

• You consume alcohol heavily

• You are pregnant or breastfeeding (consult a doctor)

Use with caution if:

• You have heart disease

• You are elderly

• You have adrenal/pituitary disorders

• You skip meals regularly (risk of hypoglycemia)

Major interactions

Avoid or discuss with a doctor:

• Alcohol

• Steroids

• Diuretics

• Thyroid medicines

• Beta-blockers (can hide low sugar symptoms)

Benefits

• Provides strong control of both fasting and post-meal sugar

• Helps delay diabetes complications

• Improves insulin efficiency

• Often reduces HbA1c significantly (1–2% range)

• Convenient combination therapy (two medicines in one tablet)

Avoid Taking Glycomet-GP 3 If

• You are allergic to Glimepiride or Metformin

• You have DKA (diabetic ketoacidosis)

• You are undergoing major surgery

• You are scheduled for contrast dye/X-ray procedures (metformin may need to be stopped temporarily)

Side Effects

Common:

• Low blood sugar (hypoglycemia)

• Nausea

• Stomach discomfort

• Diarrhea

• Dizziness

• Headache

• Weight gain (due to Glimepiride)

Serious (seek medical help):

• Severe hypoglycemia (sweating, confusion, shaking)

• Lactic acidosis (rare but serious):

  • Rapid breathing

  • Stomach pain

  • Weakness

  • Slow heartbeat

• Allergic rash

• Yellowing of eyes/skin (liver issue)

Where to Store

• Store below 25°C, in a dry place.

• Keep in the original blister pack.

• Protect from moisture and heat.

• Keep out of reach of children.

Conclusion

Glycomet-GP 3 is an effective combination therapy for Type 2 Diabetes, especially for people whose blood sugar is not controlled with single medicines. Glycomet-GP 3 improves insulin use and reduces blood sugar throughout the day.

However, due to the risk of hypoglycemia (from Glimepiride) and lactic acidosis (from Metformin), it must be used strictly under medical supervision, with regular sugar monitoring.

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